Complex III2 Assembly
Contributor: Giampaolo Morciano
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Theorem
Information
The third complex of the electron transport chain (CIII, also termed coenzyme Q : cytochrme c - oxidoreductase or cytochrome bc1 complex) is located at the inner mitochondrial membrane (IMM), especially at cristae compartment, catalalyzing the reduction of cytochrome c by the oxidation of coenzyme Q with the concomitant pumping of 4 H+ to the intermembrane space. The architecture of CIII consists in a multi-subunits symmetrical dimer (CIII2), where 1 mitochondrial DNA and 9 nuclear genes encode the structural proteins forming each monomer.
References:
Crofts AR. The cytochrome bc1 complex: function in the context of structure. Annu Rev Physiol. 2004;66:689-733. doi: 10.1146/annurev.physiol.66.032102.150251. PMID: 14977419.
Fernandez-Vizarra E, Zeviani M. Mitochondrial complex III Rieske Fe-S protein processing and assembly. Cell Cycle. 2018;17(6):681-687.doi:10.1080/15384101.2017.1417707. Epub 2018 Apr 10. PMID: 29243944.
Cogliati S, Enriquez JA, Scorrano L. Mitochondrial Cristae: Where Beauty Meets Functionality. Trends Biochem Sci. 2016 Mar;41(3):261-273. doi:10.1016/j.tibs.2016.01.001. Epub 2016 Feb 6. PMID: 26857402.
Link to other Databases:
HumanCyc: https://humancyc.org/HUMAN/NEW-IMAGE?type=ENZYME&object=CPLX66-558
Mitochondrial processes
Demonstrative and biological steps
Dynamic view
Mito-location
Not Available/Not Relevant
Matrix
Inner Membrane
Inter-Membrane Space
Outer Membrane
